Affordable Molecular diagnostics for TB is key to improve the detection rate of Active TB / MDR TB in the Country.
Description
Tuberculosis has been the leading cause of death from a single infectious agent since long, if we exclude the recent COVID-19 phenomena. India is the worst TB affected Country in the world accounting for ∼26% of the total cases.
“For the first time in over a decade, TB deaths have increased because of reduced access to TB diagnosis and treatment in the face of the COVID-19 pandemic” - Dr Tereza Kasaeva Director, WHO Global TB Programme"
Since the Tubercu...
Tuberculosis has been the leading cause of death from a single infectious agent since long, if we exclude the recent COVID-19 phenomena. India is the worst TB affected Country in the world accounting for ∼26% of the total cases.
“For the first time in over a decade, TB deaths have increased because of reduced access to TB diagnosis and treatment in the face of the COVID-19 pandemic” - Dr Tereza Kasaeva Director, WHO Global TB Programme"
Since the Tuberculosis Bacteria is extremely resilient and intelligent, it adapts quickly to medications and develops resistance, which is the key reason behind prevalence of multi-drug and extreme drug resitant TB variants. Therefore, key to addressing the problem is rapid and extensive diagnosis at macro scale across the country and rollout of long course treatment as per prescribed norms.
Currently, the only confirmatory tests to diagnose active TB are:
1. Culture – Takes several days first to detect and then to run Drug Susceptibility tests
2. Nucleic Acid Amplification – Minimum CAPEX of ₹7.5 Lakh(10k$), and need for skilled lab technicians. Point of care solutions like Cepheid GeneXpert, and Molbio Trueprep + Truelab are very expensive
We are developing a truly affordable point of care molecular diagnostic solution for Tuberculosis which will also give quick results in 30-40 mins.
Organization
STRUmed Solutions Private Limited
Budget
Target end user pricing for equipment < INR 1 lakh and per test cost < INR 400
Impact
Towards TB eradication programme: - Offering affordable point of care Molecular Diagnostic equipment priced less than 1 lakh INR - No need for skilled technicians for pipetting and other such needs - Single automated equipment which will combine Nucleic Acid Extraction, Amplification and Detection processes
Deployments
Innovation
Using novel Isothermal Amplification methods for detection of Tuberculosis and Multi-drug (Rifampicin/Isoniazid) resistant Tuberculosis at point of care.
Timeline
Months
Pilots
Only in-house testing done so far. Pilots shall be done post completion of clinical evaluation. Collaborated with SMIMER Hospital & Medical College for clinical evaluation - Ethical Committee approval and Local Research Advisory Committee approval already obtained. Principal Investigator: Dr. Hetal Desai, MD [Professor & Head, Physiology], – Nodal Officer MRU – ICMR. Co-investigator: Dr. Pradeep Barde, MD [Asst. Professor Physiology] – AIIMS Rajkot.
Solver's Location
Surat, India
Website
https://www.strumed.com
Sectors
Sustainable Development Goals
This solution addresses the following problems.
USAID/India’s Accelerator to End TB in India BAA wants to rapidly demonstrate and rigorously test person-centered, high- impact and novel so
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